摘要
目的:制备复方司帕沙星滴鼻液并考察其稳定性。方法:选择稀配法配制滴鼻液;采用紫外-可见分光光度法及旋光法测定其中主药含量,并考察室温留样6mo内的药物浓度及其稳定性,同时用家兔做鼻黏膜刺激性实验。结果:司帕沙星检测浓度线性范围为2.0~9.0μg·mL^-1(r=0.9999),平均回收率司帕沙星为99.19%(RSD=1.77%),盐酸麻黄碱为100.21%(RSD=2.12%);该制剂对鼻黏膜的刺激性小,室温贮存6mo内质量稳定。结论:该制荆制备及含量测定方法简单可行,且质量稳定、刺激性小,易于推广。
OBJECTIVE : To prepare compound sparfloxacin nasal drops and to investigate the stability of this preparation. METHODS: Compound sparfloxacin nasal drops were prepared with distilled water as diluents, and the concentration of the chief component were determined by ultraviolet - visible spectrophotometer. The concentration and stability of the sample preparation were investigated after storage for 6 months at room temperature. Meanwhile nasal mucosa stimulus property test was performed on rabbits. RESULTS: The linear range of sparfloxacin was 2.0-9.0μg·mL^-1(r = 0.999 9), with average recovery at 99.19% (RSD = 1.77% ), and that of ephedrine hydrochloride was 100.21% (RSD = 2.12% ) . The preparation showed a minor stimulation on nasal mucosa and was stable in quality within 6 months after storage at room temperature. CONCLUSION: The preparation is simple and practical in preparation and determination, stable in quality and minor in stimulation, thus deserving to be popularized.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第4期289-290,共2页
China Pharmacy
关键词
复方司帕沙星滴鼻液
制备
含量测定
稳定性
Compound sparfloxacin nasal drops
Preparation
Determination of content
Stability