紫外分光光度法测定草酸右旋依地普仑片的溶出度

Determination of the Dissolution of Escitalopram Oxalate Tablets by Ultraviolet Spectrophotometry

目的：建立测定草酸右旋依地普仑片溶出度的方法。方法：采用紫外分光光度法在239nm波长处测定其吸收度，并计算回收率和溶出度。结果：草酸右旋依地普仑检测浓度在2．5～30μg·mL^-1范围内与吸收度呈良好线性关系（r=0．9999），平均回收率为100．64％（RSD=0．49％）；3批样品的30min溶出度均在90％以上。结论：本方法简便、准确，结果可靠，可用于草酸右旋依地普仑片的溶出度测定。

OBJECTIVE： To establish a method for the determination of the dissolution of eseitalopram oxalate tablets. METHODS： The absorbability of escitalopram oxalate tablets was detected by ultraviolet spectrophotometry at a wavelength of 238nm, and the recovery and dissolution of which were calculated. RESULTS： The linear range of escitalopram oxalate tablets was 2.5-30μg · mL^ -1（ r = 0.999 9）, and its average recovery was 100.64% （RSD = 0.49%）. The dissolutions of 3 batches of samples were all above 90%. CONCLUSION： The method is simple, accurate, reliable, and suitable for the determination the dissolution of escitalopram oxalate tablets.