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转化生长因子-β与骨关节炎的软骨损伤修复 被引量：10

Transforming growth factor-β in the repair of cartilage disorders caused by osteoarthritis
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摘要 转化生长因子-β(TGF-β)具有广泛的生理效应。它在软骨细胞代谢中起着十分重要的作用,在体外,TGF-β可促进软骨基质分泌、细胞增生、骨软骨生成分化;在体内,短期关节腔内注射可增加骨和次级软骨细胞生成、骨软骨发生。体内TGF-β的诱导表达和基因转移给骨关节炎带来了新的治疗手段。 Transforming growth factor-β （TGF-β） plays a significant role in promoting chondrocyte anabolism in vitro and in vivo. Induction of the expression of TGF-β in vivo and the gene transfer may provide a new approach for treatment of osteoarthritis.
作者 何炜 郭亭 赵建宁
机构地区 南京军区南京总医院南京大学医学院临床学院骨科
出处 《医学研究生学报》 CAS 2007年第2期195-198,共4页 Journal of Medical Postgraduates
基金 江苏省自然科学基金面上项目基金资助(批准号:BK2005085)
关键词 骨关节炎 转化生长因子-Β 软骨细胞代谢 Osteoarthritis Transforming growth factor-β Chondrocyte metabolism
分类号 R681.3 [医药卫生—骨科学]
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参考文献20

  • 1Frenkel SR,Saadeh PB,Mehrara BJ,et al.Transforming growth factor beta superfamily members:role in cartilage modeling[J].Plast Reconstr Surg,2000,105(3):980-990.
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  • 4Ferguson CM,Schwarz EM,Reynolds PR,et al.Smad 2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation[J].Endocrinology,2000,141(12):4728-4735.
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  • 10郭亭,赵建宁.关节软骨缺损的治疗进展[J].医学研究生学报,2004,17(8):744-748. 被引量：10

二级参考文献20

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  • 5[5]Bentley G, Biant LC, Carrington RW et al. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee[J]. J Bone Joint Surg Br, 2003, 85(2):223-230.
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  • 10[10]Hangody L,Kish G,Karpati Z et al. Three to six year results of autologous osteochondral mosaicplasty on the talus[J].Foot Ankle Int,2001,22:552-558.

共引文献9

同被引文献145

引证文献10

二级引证文献138

医学研究生学报
2007年 第2期

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