干扰素壳聚糖/海藻酸钠微囊控释制剂载体的初步研究

Preliminary Study on Chintosan/Sodium Alginate as Carriers of Control-released Interferon Microcapsule

目的研究蛋白质类药物口服控释给药的可行性。方法壳聚糖与海藻酸钠通过聚电解质络合反应制备成壳聚糖/海藻酸钠微囊,以干扰素为模型药物,研究不同pH条件下,药物的控制释放情况。结果微囊的粒径为1 mm左右,其干扰素的包封率达90.0%以上,微囊在模拟胃液(pH1.0)中,3h药物释放不到5%;在模拟肠液(pH7.4)中,3h药物释放近100%。结论壳聚糖/海藻酸钠微囊有可能成为蛋白质类药物口服控释制剂的载体。

Objective To explore the feasibility of protein drugs as control-released microcapsules. Methods Prepare interferon microcapsules with chitosan and sodium alginate by polyelectrolyte complexation and study the control-release of interferon at different pH values. Results The mean particle size of the prepared microcapsules was about 1 ram,and the envelopment rate of interferon reached more than 90. 0%. The release rate of interferon after standing for 3 h in mimic gastric juice（pH 1.0） was less than 5%. However, after standing in mimic intestinal juice for 3 h, the release rate of interferon reached nearly 100%. Conclusion Chitosan/sodium alginate might be a potential carrier of control-released microcapsule of protein drugs.