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视网膜色素变性的自然动物模型及人工造模 被引量:4

Nature and medicine-induced animal model of retinitis pigmentosa
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摘要 遗传性视网膜色素变性(RP)是成人遗传性致盲眼病中最常见的疾病。到目前为止,这种疾病还没有有效的治疗方法。RP动物模型分为自然动物模型及人工造模,它们又分别包括不同的动物及种类,每种都有其不同的特点。探索RP的治疗方法需要合适的动物模型。就RP动物模型的种类及机制做一综述。 Retinitis pigmentosa is the most common cause in adults hereditary disorders leading to blindness. There are currently many experimental researches in effort to develop an effective therapy for retinitis pigmentosa. Thus, an appropriate animal model is necessary for the progression in relevant experiments. Two types of animal models are offered, that is natural and artificial ones, and each also include different animals and types. Variant retinitis pigmentosa phenotypes have been found in nature type in mouse, rat, dog, cat, ect. , in which mouse and rat are earliest utilized as animal models of retinitis pigmentosa, whose pathologic process and phenotypes have been thoroughly investigated. Transgenic animals and chemical drugs are also applied in attempts to find more feasible animal models. Owing of the relatively large volume of eye, transgenic pigs are thought to be very good retinitis pigmentosa models during operation on the eyes. With respect to the chemical drugs, NaIO3 is most frequently used in ophthalmology. In addition,light with different wavelengths is also used to induce the damage of different ocular tissue. Characteristics and pathology of different animal models are overviewed.
出处 《眼科研究》 CSCD 北大核心 2007年第2期157-160,共4页 Chinese Ophthalmic Research
关键词 视网膜色素变性 动物模型 转基因动物 化学造模 retinitis pigmentosa animal model transgenie animal medicine-induced animal model
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  • 1Doonan F,Cotter TG.Apoptosis:a potential therapeutic target for retinal degenerations[J].Curr Neurovasc Res,2004,1:41-53
  • 2Carter DLD,LaVail MM,Sidman RL.Differential effect of the rd mutation on rods and cones in the mouse retina[J].Invest Ophthalmol Vis Sci,1978,17:489-498
  • 3Dalke C,Loster J,Fuchs H,et al.Electroretinography as a screening method for mutations causing retinal dysfunction in mice[J].Invest Ophthalmol Vis Sci,2004,45:601-609
  • 4Bourne MC,Campbell DA,Tansley K.Hereditary degeneration of rat retina[J].Br J Ophthalmol,1938,22:613-623
  • 5Lue CL.Rod cell activity in retinal degenerative rats[J].J Formos Med Assoc,1994,93:605-610
  • 6Neuhardt TH,May CA,Wilsch C.Morphological changes of retinal pigment epithelium and choroids in rd-mice[J].Exp Eye Res,1999,68:75-83
  • 7Strauss O,Stumpff F,Mergler S.The royal college of surgeons rat:an animal model for inerited retinal degeneration with a still unknown genetic defect[J].Acta Anat,1998,162:101-111
  • 8Cruz PM,Yasumura D,Weir J.Mutation of the receptor tyrosine kinase Mertek in the retinal dystrophic RCS rat[J].Hum Mol Genet,2000,9:645-651
  • 9Andreas G,Li Y,Thompson DA.Mutations in MERTK,the human orthologue of the RS rat retinal dystrophy gene,cause retinitis pigmentosa[J].Nature genet,2000,26:270-271
  • 10Neeraj A,Catherine J,Steve EJ.Immunocytochemical colocalization of clusterin in apoptotic photoreceptor cells in retinal degeneration slow rds mutant mouse retinas[J].Biochem Biophys Res Commun,1996,225:84-91

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