摘要
本文利用ＣＮＤＯ／２法选择适当的计算模型研究了普鲁卡因的药理作用，确定了普鲁卡因分别与细胞膜上的磷脂及蛋白质结合所形成的药物一受体络合物的平衡结构．计算结果表明普鲁卡因与股磷脂的结合能大于普鲁卡因与膜蛋白质的结合能，因此起主要药理作用的药物一受体络合物可能是普鲁卡因与膜磷脂所形成的络合物．
In this paper CNDO/2 method was used to study the pharmacological effect by choosing appropriate calculation model. The equilibrium structures of durg receptor between procaine and membrane phospholipids or between procaine and membrane proteins have been studied. These calculation data suggest that the binding energy between procaine and membrane phospholipids is greater than that of procaine and membrane proteins. These show that the drug-receptor complex between procaine and membrane phospholipids plays main role in pharmacolgical effects.
出处
《哈尔滨师范大学自然科学学报》
1996年第3期39-43,共5页
Natural Science Journal of Harbin Normal University
