补体系统激活对兔出血性脑水肿的影响

Effect of activation of complement system on cerebral edema after intra cerebral hemorrhage of rabbit

目的:研究补体激活对兔脑出血性脑水肿的影响。方法:制造兔脑出血模型,随机分为实验组、对照组。实验组注射眼镜毒蛇因子,检测脑组织水含量及不同时点血浆补体C3、神经元特异性烯醇化酶、肿瘤坏死因子浓度,结果与对照组比较。结果:实验组与对照组48h后脑组织水含量分别为(80.19±0.54)、(79.57±0.44)。脑组织水含量、补体C3、神经元特异性烯醇化酶、肿瘤坏死因子浓度两组比较差异有显著性(P<0.05)。结论:脑出血后补体系统激活加重了脑水肿。

Objective：To study the effect of activation of the complement system on cerebral edema after cerebral hemorrhage of rabbit. Methods： Cerebral hemorrhagic model was established and rabbits were divided into experimental group and control one. CVF was injected intraperitoneally in the experimental group. The dry weight/wet weight of brain and the level of plasma complement C3 in different time, NSE and TNF-α were detected in the experimental group. The results of the experimental group were compared to the control one. Results：The dry weight/wet weight of the brain tissue in the experimental group and control group after 48 hrs were （80.19 ± 0.54）and（79.57 ± 0.44）, respectively. There was significant statistical difference in the experimental and control groups about the dry weight/wet weight of the brain tissue, the level of complement C3, NSE and TNF-α .（P〈 0.05）. Conclusion： The activation of the complement system after brain hemorrhage aggravates cerebral edema.