高温高湿环境下颅脑火器伤亚低温治疗的实验研究

Gurative Effect of Mild Hypothermia on Craniocerebral Firearm Wound in Megathermal and Megahumid Environment in Dogs

目的观察早期亚低温治疗高温高湿环境下犬颅脑火器伤的疗效。方法选杂种犬60只,制作出高温高湿环境下(气温39℃±0.5℃,相对湿度80%～85%)颅脑火器伤的动物模型,随机分为亚低温组和对照组,每组30只犬。亚低温组在术中采用静脉内输入1.2℃±0.34℃冷冻生理盐水,输液量为体重的5%,术后采用降温毯降温,体温控制在33～35℃,持续48h。对照组按常规治疗。Powlab/8SP生理记录仪动态监测生命体征变化和记录两组动物的生存率,分析比较二组的治疗结果。结果亚低温组动物生命体征平稳,死亡率40%(12/30);对照组动物生命体征紊乱,死亡率70%(21/30),两组死亡率差异显著(P<0.05)。结论早期亚低温治疗高温高湿环境下颅脑火器伤可以降低动物的死亡率。

Objective To investigate the effect of mild hypothermia on craniecerebral firearm wound （CFW） in megathermal and megahunfid environment in dogs. Methods CFW in megathermal （atmospheric temperature, 39°C±0.5°C） and megahumid environment （relative humidity, 80%-85%） was made by pistol in 60 dogs. The dogs with CFW were randomly divided averagely into hypothermia and control groups. The dogs in the hypothermia group were treated by intravenous infusion of cold physiological saline at （1.2±0.34）°C （5% body weight） during the operation and their body temperatures were decreased to 33-35°C with ice blanket after the operation for 48 hoursl The dogs in the control groups were given the saline at room temperature and routine treatment. Powlad/8SP physiological recorder was used to observe the changes in vital signs and the rate of survival was recorded after the treatment in both the hypothermia and control groups. The curative effects in both the groups were statistically analysed. Results The dogs＂ vital signs were stable and the mortality was 40%（12/30） in mild hypothermia group. The disturbances of vital signs were aggravated in the dogs of control group and the mortality was 70%（21/30）. There was significant difference in the mortality between the two groups （P〈0.05）. Conclusion The mild hypothermia treatment early after CFW can decrease the mortality of the dogs with CFW in megathermal and megahumid environment.