脂联素的内皮保护效应

Protective Efffect of Adiponectin in Endothelium

脂联素是一种调节能量代谢的脂肪因子。在肥胖、2型糖尿病、冠心病和其他胰岛素抵抗状态中,其血浆水平是降低的。2型糖尿病和胰岛素抵抗时常伴有内皮机能障碍,低脂联素水平和内皮功能障碍之间的密切联系已被证实。脂联素通过胰岛素增敏、抗氧化、抗动脉粥样硬化、抗炎和抗增殖等多重机制来保护内皮组织,这些血管保护效应为其作为防治心血管疾病的一种新的靶目标提供了新思路。

Adiponectin is a fat factor regulating energy metabolism,whose level is very low. in obesity, type 2 diabetes, coronary heart disease and other insulin-resistant states. Dysfunction of the endothelium is often found in patients with diabetes and other insulin-resistant states. And a close association between hypoadiponectin-emia and endothelial dysfunction has also been demonstrated. Adiponecfin can exect its protective effect through many mechanisms including insulin sensitization, antioxygen, anti-atheroeclerosis, antiinflananatory, anti-proliferation and so on. As a new target in the protection and cure of vascular diseases, these vascular protection will provide new ideas.