高同型半胱氨酸血症与脑梗死患者血液流变性变化的相关分析

Relationship Between Hyperhomocysteine and Hemorheology in Patients with Cerebral Infarction

目的:分析高同型半胱氨酸(HCY)血症与脑梗死患者血液流变性变化的相关性。方法:测定40例不同性别健康人(健康对照组)、42例正常HCY脑梗死患者(正常Hcy组)和50例高HCY脑梗死(高HCY组)患者血液流变学指标:全血低切粘度(ηbL)和高切粘度(ηbH)、血浆粘度(ηp)、红细胞压积(Hct)、血沉(ESR)、纤维蛋白原(Fib)、红细胞变形指数(TK)、红细胞聚集系数(AI),分析HCY水平与血液流变学指标的相关性。结果:高HCY血症组男女性ηp、ηbL、ηbH、AI、TK、Fib及ESR与健康对照组和正常HCY组比较有显著性差异(P<0.01);高HCY水平与脑梗死患者血液流变指标异常明显正相关。结论:高HCY血症是脑梗死患者血液流变性异常的重要影响因素。

Objective: To investigate the relation between the hyperhomocysteine and hemorheology index of the cerebral infarction patients.Method: The indexes of the hemorheology were measured in 40 healthy people,42 cerebral infarction patients with normal homocysteine and 52 patients with hyperhomocysteine. These indexes were low shear and high shear viscosity of the whole blood 、plasma viscosity、Hct、ESR、Fib、TK and AI. Results: The whole blood viscosity、plasma viscosity、AI、Fib、TK and ESR of the patients with hyperhomocysteine were much higher than that of the control patients; there was a positive correlation associativity between the hyperhomocysteine and the indexes of hemorheology.Conclusion: The hyperhomocysteine play an important role in abnormal hemorheology in the cerebral infarction patients.