肝细胞生长因子及其受体c-Met在喉鳞状细胞癌中的表达

Hepatocyte growth factor and c-Met receptor expression in cancer of larynx

目的探讨肝细胞生长因子(HGF)及其受体c-Met蛋白表达与喉鳞状细胞癌临床病理特征的关系。方法应用免疫组化法检测25例正常喉黏膜,46例喉鳞状细胞癌组织中HGF及c-Met蛋白的表达。结果(1)正常喉黏膜HGF及c-Met低表达或阴性。(2)喉鳞状细胞癌c-Met表达与临床分期、病理分级明显相关(P<0.05),Ⅰ、Ⅱ期低于Ⅲ、Ⅳ期。无淋巴结转移低于有淋巴结转移(P<0.05)。半定量分析:HGF表达与喉鳞状细胞癌Ⅲ+Ⅳ期有关(P<0.05)。结论HGF/c-Met系统在喉鳞状细胞癌的侵袭进展中起重要作用,c-Met可能成为判断喉鳞状细胞癌预后的良好参考指标。HGF及c-Met联合检测对于判断喉鳞状细胞癌预后有重要意义。

Objective To study the relationship between HGF,c-Met protein expression and the clinico pathological figures in patients with cancer of larynx. Methods Immunohistochemistry was used to examine the protein expression of HGF and c-Met,in 46 cases of cancer of larynx tissue and 20 corresponding normal tissues. Results （1） In normal membrana mucosa laryngis, there were poor protein expression of HGF and c-Met. （2）In cancer of larynx, expression of c-Met was significantly correlated with surgical stage Ⅲ and Ⅳ ,histologic grade 3 （P〈0. 05）, but was not correlated with age, invasion and lymph metastasis（P〉0. 05） . HGF expression was significantly correlated with surgical stage Ⅲ and Ⅳ by semequantitative and analysis. Conclusion The expression of HGF and c-Met play a key role in the development of cancer of larynx. The expression of c-Met might be a useful prognostic factor of patients with cancer of larynx. The colocation of both HGF and c-Met may be a significant factor in the prognosis of cancer of larynx.