肺表面活性物质疗效影响因素的探讨

Factors affecting the curative effects of surfactant

目的探讨影响肺表面活性物质(PS)疗效的因素。方法分治愈组及死亡组总结分析使用肺表面活性物质治疗25例新生儿肺透明膜病的情况。结果使用PS前两组血pH、PCO2比较有统计学意义;孕周、出生体重、出生窒息史、PS剂量比较有统计学意义。缓慢给药病例与快速给药病例肺出血、脑出血、动脉导管重新开放等并发症比较,差异有统计学意义。结论早期足量使用PS,使用前注意改善通气、纠正酸中毒,PS注入速度应缓慢,以不少于15min为宜。

Objective： To illuminate the factors affecting the curative effects of pulmonary surfactant （PS） . Methods： 25 inhospital neonates with hyaline membrane disease were allocated into healing group and death group and treated with PS. Results： Significant difference was found in pH and PCO2 between the two groups before treating with PS. There were significant differences about pregnant weeks, birth weight, apnea and dosage of PS between the two groups. And incidence of complications such as pulmonary hemorrhage, cerebral hemorrhage, and pulmonary arterial duct reopening between the slowly instilled and quick instilled cases had significant differences. Conclusion： Sufficient dosage and early use of PS and improvement of ventilation, correction of acidosis before given PS and instillation of PS no less than 15 minutes are very necessary.