31例West综合征临床与脑电图分析

The clinical manifestations and the analysis of EEG of 31 children with West syndrome

目的:探讨31例W est综合征患儿的临床与脑电图改变。方法:对临床表现符合或疑似W est综合征患儿进行常规脑电图检测,对于未发现癫痫波形或发现疑似癫痫波形的病例进行24 h动态脑电图检测。结果:31例患儿脑电图均为异常:高峰失律(74.20%),变异性高峰失律(6.45%)或其它形式异常脑电图(19.30%)。结论:婴儿痉挛症除典型发作形式和精神运动发育障碍(本组病例78.20%)外,具有特异性脑电图改变(高峰失律)。脑电图是确诊婴儿痉挛症的重要依据。

Objective： To explore the clinical manifestation and the change of EEG of 31 children with West syndrome. Methods： Children whose clinical manifestations consistented with or resembled those of West syndrome underwent routine EEG monitoring; Children whose routine EEG without characteristic abnormalities or conspicuous ones underwent 24 hours ambulatory EEG monitoring. Results： All EEGs/24 hours ambulatory EEGs displayed characteristic hypsarrhythmia （74. 2% ）, its variants （6. 45% ） or other abnormal patterns （ 19. 3 % ） . Conclusion： West syndrome has characteristic hypsarrhythmia EEG besides the phenomenon of spasm clusters and the association with mental and/or developmental retardation. EEG is an important tool to definite the diagnosis of West syndrome.