精神分裂症探究性眼动分析与P300电位研究

A study on exploratory eye movement and P300 potentials with 42 schizophrenic Patients.

目的探讨精神分裂症患者探究性眼动分析与P300电位对精神分裂症患者的诊断价值。方法对42例精神分裂症患者和40例正常健康者分别进行探究性眼动分析与P300电位测定,并进行比较分析。结果精神分裂症组中探究性眼动分析和P300电位测定的异常率分别为85.7%和81.0%,两者异常吻合率为76.2%。精神分裂症组探究性眼动测定结果中凝视点和反应探索评分值显著低于对照组(P<0.01),P300电位测定中N2、P3波潜伏期和P3波幅较对照组分别延长和降低(P<0.01)。结论探究性眼动分析和P300电位测定可作为精神分裂症患者的诊断指标应用于临床。

Objective To explore the diagnostic value of exploratory eye movement and P300 potentials in schizophrenic patients. Methods Exploratory eye movement（EEM）and P300 potentials test were used for forty-two schizophrenic patients and forty healthy people, and the results were compared in the two groups. Results The abnormal rates of EEM and P300 potentials test in schizophrenic group were 85.7 （36/42）and 81.0%（34/42） respectively. The abnormal identical rate of the two indexes was 76.2% （32/ 42）. The number of eye fixation（NEF）and the responsive search score（RSS）in schizophrenic group were significant lower than those in the control group（P^0.01）. The latency of N2 and P3 of p300 potentials and the amplitude of P3 of p300 potentials in schizophrenic group were longer and lower than those in the control group. There were significant difference between the two groups（P〈0.01）. Conclusion Exploratory eye movement and p300 potentials test have remarkable clinical value as diagnostic indexes with schizophrenic patients.