奎硫平与氯氮平对精神分裂症的疗效及认知功能影响的比较研究

Comparative study of curative effects and influence on cognitive function of quetiapine and clozapine in schizophrenia

目的探讨奎硫平与氯氮平对精神分裂症的疗效及认知功能的影响。方法将120例精神分裂症患者随机分为两组,每组各60例,研究组给予奎硫平治疗,对照组给予氯氮平治疗,疗程8 w。与治疗前及治疗2 w,4 w,6 w,8 w末采用潘氏量表和副反应量表评定临床疗效及不良反应。结果研究组显效率为78.3%,总有效率为95.0%;对照组显效率为75.0%,总有效率为90.0%,两组总体疗效相当(P>0.05)。研究组认知功能的改善较对照组显著,治疗2 w末差异有显著性(P<0.05),4 w,6 w,8 w末差异均有极显著性(P<0.01)。研究组不良反应较对照组发生率低,且程度轻。结论奎的平治疗精神分裂症疗效显著,能显著改善患者的认知功能,安全性高,依从性好。

Objective To explore the curative effects and influence on cognitive function of quetiapine and clozapine in the treatment of schizophrenia. Methods 120 schizophrenics were randomly divided into research group（n= 60, took quetiapine） and control group（n= 60, did clozapine） for 8 weeks. The curative effects were assessed with the Positive and Negative Syndrome Scale（PANSS） and adverse effects with the Treatment Emergent Symptoms Scale（TESS） before treatment and at the ends of the 2nd, 4th,6th and 8th week treatment. Results In the research group, excellence and total effectual rate was respectively 78.3% and 95.0%, and in the control group 75.0% and 90.0%, total curative effects of both 2 groups were equivalence（P〉0.05）. Cognitive improvement was more obvious in the research than in the control group, difference was significant at the end of the 2nd week（P〈0.05） and very significant at the ends of the 4th, 6th and 8th week（P〈0.01）. Compared with the control group, incidence of adverse effects were lower and their degrees milder in the research group. Conclusion Quetiapine has notable efficacy especially on cognitive functions, higher safety and better compliance in the treatment of schizophrenia.