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细胞因子及其基因多态性在精神分裂症中的研究进展 被引量：4

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作者 宋学勤 赵靖平 吕路线
机构地区 郑州大学第一附属医院精神科 中南大学湘雅二医院精研所 新乡医学院第二附属医院
出处 《临床心身疾病杂志》 CAS 2007年第1期79-84,共6页 Journal of Clinical Psychosomatic Diseases
基金 "十五"国家科技攻关计划项目资助(编号2004BA720A22) 河南省科技攻关计划项目资助(编号0624410037)
关键词 精神分裂症 细胞因子 基因多态性 生物功能
分类号 R749.3 [医药卫生—神经病学与精神病学]
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参考文献40

  • 1Wilson AG, Symons JA, McDowell TL, et al. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation[J]. Proc Natl Acad Sci U S A,1997,94(7):3195
  • 2Bailly S,Israel N, Fay M, et al. An intronic polymorphic repeat sequence modulates interleukin-1 alpha gene regulation[J]. Mol Immunol, 1996, 33(11-12) :999
  • 3秦玉新,张庆柱.内毒素作用中的蛋白质和信号通路[J].中国药理学通报,2003,19(12):1336-1339. 被引量：12
  • 4Dominici R, Cattaneo M, Malferrari G. et al. Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1 alpha[J]. Immunogenetics, 2002,54 (2) : 82
  • 5Santtila S, Savinainen K, Hurme M. Sence of the IL-1RA allele 2 (IL1RN * 2) is associated with enhanced IL-1beta production in vitro[J]. J Immunol, 1998,47(3) : 195
  • 6Katila H, Hanninen K, Hurme M. Polymorphisms of the interleukin-1 gene complex in schizophrenia[J]. Mol Psychiatry, 1999,4(2) : 179
  • 7Zanardini R, Bocchio-Chiavetto L, Scassellati C, et al.Association between IL-1beta -511C/T and IL-1RA (86bp)n repeats polymorphisms and schizophrenia [-J ]. J Psychiatr Res,2003,37(6) :457
  • 8Kim SJ, Lee H J, Koo HG, et al, Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder[J].Psychiatr Genet,2004,14(3):165
  • 9Papiol S, Molina V, Desco M, et al. Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene[J].Neuroimage, 2005,27 (4) : 1002
  • 10Rosa A, Peralta V, Papiol S, et al. Interleukin-1beta(IL-1beta) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders[J].Am J Med Genet B Neuropsychiatr Genet, 2004,124( 1): 10

二级参考文献46

  • 1Kendler KS. The genetics of schizophrenia : an overview. In: Tsuang MT, Simpson JC (Eds) .Handbook of Schizophrenia, Volume 3, Nosology, Epidemiology and Genetics of Schizophrenia. Amsterdam.Elsevier, 1988, 437 - 462.
  • 2Ganguli R, Yang Z, Shurin G, et al. Serum interlukin - 6 concentration in schizophrenia: elevation associated with duration of illness. Psychiatry Research. 1994, 51, 1 - 10.
  • 3Mcallister CGV, Kammen DP, Kelley ME.Relapse prediction in schizophrenia : from monoamines to cytokines. In: Ebert D, et al(Series Eds) .Advances in Biological Psychiatry, volume 18. In:Henneberg AE, Kaschka WP (Eds) . Immunological Alterations in Psychiatric Diseases. Basel. Karger, 1997, 44 - 49.
  • 4Hopkins S.I, Rothwell N.I. Cytokines and the nervous system I:Expression and regulation.Trends in Neuroscience. 1995, 18, 83- 88.
  • 5Mehler MF, Kessler JA. Hematolymphopoetic and inflammatory cytokines in neural development. Trends in Neurescience, 1997, 20,357 - 365.
  • 6Merrill JE. Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: Normal and pathological. Developmental of Neuroscience, 1992, 14, 1-10.
  • 7Vitkovic L, Bockaert J, Jacque C. "Inflammatory" cytokines:Neuromodulators in normal brain? Journal of Neurochemistry.2000, 74, 457-471.
  • 8Gilmore JH, Jarskog LF. Exposure to infection and brain development: Cytokines in the pathogenesis of schizophrenia. Schizophrenia Research, 1997, 24, 365-367.
  • 9Bothwell NJ, Hopkins SJ. Cytokines and the nervous system Ⅱ:Action and nechanisms of action.trends in Neuroscienee, 1995,18, 130- 136.
  • 10Loddick SA. Rothwel NJ. Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin - like growth factor - 1. Proceeding of the National Academy of Sciences of the United States of America, 1999, 96, 9449 - 9451.

共引文献22

同被引文献57

引证文献4

二级引证文献14

临床心身疾病杂志
2007年 第1期

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