软肝胶囊对二甲基亚硝胺所致大鼠慢性肝损伤的保护作用

Protective Role of Ruangan Capsule in Antagonizing Chronic Damage of Rat Liver Caused by Dimethyl Nitrosamine

目的观察软肝胶囊对二甲基亚硝胺(DMN)所致大鼠慢性肝损伤模型的保护作用。方法模型组及各给药组腹腔注射DMN10mg/kg,正常对照组给予等容积生理盐水,每周2次,连续2d注射,持续4周,给药自造模之日开始,1次/d。结果给予软肝胶囊的0.7,1.4,2.8g/kg三个剂量组肝功能指标均有不同程度的改善,肝组织羟脯氨酸含量较模型组明显降低;2.8g/kg剂量组血清HA,LN的值较模型组显著降低;病理组织学检查结果表明,其肝脏病变程度均较模型组明显减轻。结论软肝胶囊对慢性肝损伤大鼠具有一定的保护作用。

Objective To observe the protective role of Ruangan capsule in antagonizing chronic damage of rat liver caused by dimethyl nitrosamine （DMN）. Methods Hepatic damage was induced via celiac injection of DMN at a dose of 10 mg/kg （twice per week for 4 weeks）. Results The parameters reflecting liver function were significantly improved in the three groups administered with various dose of Ruangan capsule, and their hydroxyproline it, the liver tissue declined clearly. Also, their serum hyaluronic acid and laminin levels went dnwn obviously in the group with Ruangan capsules at a dose of 2.8 g/kg. Furthermore, the histopathological improvement in the dearee of liver lcsion was achieved in Ruangan capsule groups. Conclusion Ruangan capsule plays a protective role in antagomzug chronic damage of rat liver to some extent.