cyclin E与P27蛋白在子宫腺肌病中的表达及临床意义

Study On Expression of Cyclin E and p27 in Adenomyosis and Their Clinicai Significance

目的探讨周期素E(cyclinE)与P27蛋白在于宫腺肌病中的表达及意义。方法对40例子宫腺肌病(观察组)采用免疫组织化学的方法(S-P)检测cyclinE与P27蛋白的表达,并与30例正常宫内膜组织(对照组)相比较。结果cyclinE在子宫腺肌病中的表达明显高于正常宫内膜组织,P27蛋白在子宫腺肌病中的表达明显低于正常宫内膜组织,经统计学处理差异有显著性(P<0.05)。在子宫腺肌病中,cyclinE高表达及P27低表达与痛经、异位内膜浸润肌层深度及腺肌瘤的大小有关,而与月经过多无明显关系。结论cyclinE及P27蛋白与子宫腺肌病的发生、发展关系密切。

Objective To study the expression of cyclin E and p27 in adenomyosis and their clinical significance. Methods Immunohistochemical S-P method was employed to detect the experession of cyclin E and p27 in adenmyosis group （40 cases） and mormal endometrial tissue group （30 cases, control group）. Results Cyclin E expression level was found to be statistically higer in adenomyosis than in noemal tissue （ P 〈 0.05 ）, Significant difference in p27 exprssion was observed between the adenomyosis group and the control group. The expression level of p27 was found to be higher in the control group than in the adenmyosis group （ P 〈 0.05 ）. The high expression of cyclin E and the low expression of p27 in uterine leiomyoma were closely related to dysmenorrhea, the infiltration depth of endometriosis, and the size of adenomyoma, but had no relation to menorrhagia. Conclusion As cell cycle regulatory factors, p27 and cyclin E might be invoved in the development of adenomyosis. The synergistic effect of the chants in cyolin E and p27 may promote the develoment of adenomysis and predict patients＇poor prognosis.