摘要
为探讨EB病毒原位杂交的表达与鼻咽癌(NPC)各组织学类型的关系,用EB病毒原位杂交方法对NPC69例、NPC淋巴结转移11例、非NPC淋巴结转移性鳞状细胞癌10例进行研究。结果:角化型鳞状细胞癌12例全部阴性,非角化型鳞状细胞癌54例全部阳性,腺癌3例阴性;NPC淋巴结转移11例全部阳性,非NPC淋巴结转移癌10例中9例阴性,1例阳性;癌旁粘膜上皮及间质淋巴细胞阴性。提示EB病毒原位杂交表达与NPC的组织学类型关系密切,角化型为阴性表达,非角化型为阳性表达。
In order to find the relationship between the histological type of nasopharyngeal carcinoma(NPC) and the expression of Epstein Barr virus(EBV) by in situ hybridization,69 cases of NPC,11 cases of NPC lymph node (LN) metastasis and 10 cases of non NPC squamous cell carcinoma LN metastasis were studied to reveal the relationship between the histololgical type of NPC and the expression of EBV by in situ hybridization.Results:12 cases of keratinizing squamous NPC were all negative,while 54 cases of non keratinizing squamous NPC were all positive;3 cases of NP adenocarcinoma were negative;11 cases of NPC LN metastasis were all positive,while among the 10 cases of non NPC LN metastasis 9 were negative and one positive;the mucosal epithelia adjacent to the carcinoma foci and the infiltrating lymphocytes in the stroma were negative.The results suggested that the expression of EBV was closely correlated to the histological type of NPC:keratinizing NPC was negative,while non keratinizing NPC was positive.
出处
《广西医科大学学报》
CAS
1996年第4期10-13,共4页
Journal of Guangxi Medical University
基金
自治区教委科研基金
关键词
EB病毒
鼻咽肿瘤
淋巴结转移
组织学分类
Epstein Barr virus
neoplasm of nasopharynx
LN metastasis
hybridization