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186例儿童急性淋巴细胞白血病免疫表型特征 被引量：3

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摘要 目的回顾分析186例儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)免疫表型结果,以期了解儿童ALL免疫表型的特征,为临床诊断、微小残留病(minimal residual disease,MRD)的监测提供依据。方法采用多参数流式细胞术(multiparameter flow cytometry,MFC),利用CD45PE-cy5/SS设门,完成186例儿童ALL病人的免疫分型。结果在186例ALL中,B系ALL78．5％(146/186),T系ALLl9．3％(36/186),T/M混合型ALL1．1％(2/186),B/M混合型ALL1．1％(2/186)。白血病相关免疫表型(characterization of leukemia-associated immunotyping,LAIP)的出现频率为:B-ALL CD19+/CD10+/CD117+1．4％; CD19+/CD10+/CD13+25．3％;CD19+/CD10+/CD33+21．3％;CD19+/CD10+/CD2+5．5％;CD10+/CD34+/CD45±86．9％;CD19+/ CD34+/CD20+24．7％;CD19+/CD10++/CD45±67．1％;CD19+/CD10-/CD20-4．1％。T-ALL CD7+/CD13+/CD45±5．6％;CD7+/ CD33+/CD45±2．8％;TdT+/CD3+/CD45±100％;CDT++/CD2±/CD45±77．8％;CD7+/CD4+/CD3-16．7％;CD7+/CD8+/CD3- 16．7％。结论儿童B-ALL比率高于T-ALL,约为T-ALL的4倍,混合细胞白血病在儿童很少见。而且儿童ALL均具有独特的LAIP特征,因此免疫表型分析对于白血病的诊断和MR监测可提供非常客观的依据。
作者 朱明清 耿美菊 何海龙 王爱清 陈黎
机构地区 苏州大学医学院重点实验室 苏州大学附属儿童医院血液科
出处 《中国血液流变学杂志》 CAS 2006年第4期556-557,共2页 Chinese Journal of Hemorheology
关键词 急性淋巴细胞白血病 流式细胞术 免疫表型 微小残留病
分类号 R733.71 [医药卫生—肿瘤]
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参考文献6

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同被引文献27

  • 1张敬宇,吕涛,杨敬慈,潘崚,罗建民,杨琳,姚丽,董作仁,徐世荣.胞浆CD79a和其它B系相关抗原在急性白血病细胞表达的比较研究(英文)[J].中国实验血液学杂志,2005,13(6):954-958. 被引量：1
  • 2Thomas X, Archimbaud E,Charrin C, et al . CD34 expression is associated with major adverse prognostic factors in adult acute lymphohlastic leukemia[J]. Leukemia , 1995,9(2) :249.
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  • 6Pieters R, Boer MD, Durian M, et al . Relation between age immunnophenotype and vitro drug resistance in 395 children with acute lymphoblastie leukemia implication for treatment of infants[J]. Leukemia ,1998,12(9) :1344-1348.
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  • 9Thomas X,Archimbaud E,Charrin C,et al.CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia. Leukemia . 1995
  • 10Preti H A,Huh Y O,Brien O,et al.Myeloid markers in adult acute lymphoblastic leukemia. Cancer . 1995

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中国血液流变学杂志
2006年 第4期

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