制动对骨骼肌的影响及机制

Effect and Mechanism of Immobilization on Skeletal Muscle (review)

制动作为肌肉、骨骼系统损伤的一种常用治疗方法,对促进伤病的康复有重要作用。但制动也具有负面效应,对肌肉系统影响最大。笔者从制动导致骨骼肌废用性萎缩、肌力下降、肌肉血管密度降低、肌肉代谢障碍等方面阐述其影响机制,并认为在不违反医疗原则的前提下,尽可能缩短制动时间并进行早期康复干预,对消除制动带来的不利影响有重要意义。

Immobilization is a usual method to treat the injury of skeletal muscle system and plays an important role in rehabilitation of diseases. But immobilization also displays some negative effects, of all, muscle system is affected significantly. The mechanism is explored in the article from immobilization-induced skeletal muscle atrophy, the dropping of muscle power, reduction of vessels density in muscle and metabolic disturbance of muscle. The authors of the article advances that shortening the period of immobilization as possible and performing early rehabilitation are important to remove the negative influence of immobilization, but all treatments should obey the medical rules.