中药促进血虚动物白细胞增殖的药理实验研究

Experimental Study of Pharmacology of Chinese Medicine to the Proliferation of Leukocyte in Anemia Mice

目的观察中药“生白片”对小鼠血虚模型的升高白细胞、促进淋巴细胞增殖和保护DNA免受损伤的作用。方法以环磷酰胺制备小鼠血虚模型,以“生白片”加以治疗,观察治疗前后白细胞、淋巴细胞数量和微核细胞率的改变。结果“生白片”组小鼠的白细胞计数为(7.470±1.852)×109/L,淋巴细胞增殖为(14768.23±8316.86)/min,骨髓细胞微核率为(6.02±1.72)‰,均明显优于血虚模型组(P<0.01)。结论“生白片”具有明显升高白细胞、提高淋巴细胞增殖能力和降低细胞微核率的作用。

Objective To observe the effect of ＂Shengbai Tablets＂ on increasing the numbers of leucocyte, enhancing lymphocyte proliferation and reducing the micronucleus rate of cells. Methods The leukopenia model of mouse was established with cyclophosphamide, and the changes of the leukocyte count, lymphocyte proliferation and micronucleus rate before and after Shengbai Tablets treatment were observed. Results After treatment, the leukocyte count, lymphocyte proliferation and micronucleus rate of the Shengbai Tablets group were （7. 470± 1. 852） × 10^9/L, （14768.23±8316.86） and （6.02± 1. 72）‰ respectively, all were significantly better than that of the group without Shengbai Tablets treatment （P 〈0.05 ～0.01 ）. Conclusion Shengbai Tablets is able to increase the numbers of leucocyte, enhance the lymphocyte proliferation and reduce the micronucleus rate.