金童颗粒治疗抽动秽语综合征模型小鼠的药效学研究

Effect of Jintong Capsule on the Mice Models of Tourette Syndrome

目的观察金童颗粒治疗实验性抽动秽语小鼠模型的药效学作用。方法采用苯丙胺腹腔注射及阿朴吗啡皮下注射方法建立拟抽动小鼠模型,将动物随机分为正常对照组、模型组、金童颗粒大、小剂量组和氟哌啶醇对照组,观察动物的自主活动和攀爬行为,检测动物脑纹状体内多巴胺及其代谢产物的含量。结果在苯丙胺模型中,金童颗粒组小鼠的自主活动和纹状体内多巴胺含量低于模型组(P<0.05);在阿朴吗啡模型中,金童颗粒组小鼠异常攀爬时间较模型组缩短(P<0.05)。结论金童颗粒能够改善拟抽动模型小鼠异常增高的自主活动,降低其纹状体内多巴胺含量。

Objective To observe effect of Jintong capsule on model mice of tourette syndrome （TS）. Methods TS models of mouse were established by intraperitoneal injection of amphetamine （AMP） or subcutaneous injection of apomorpbine （APO）. The animals were randomly divided into the normal control group, model group, Jintong capsule large dose group, Jintong capsule small dose group and baloperidol control group. The spontaneous movements and grasping action of model animals were observed and the contents of dopamine and its products of metabolism in striatum of animals were detected. Results The abnormal hyperactivity and the content of dopamine of Jintong capsule groups in striatum of AMP model mice were lower than that of the model group （ P 〈0.05）, and the grasping time of Jintong capsule groups in APO model mice shorten compare with the control group （ P 〈0.05）. Conclusion Jintong capsule can ameliorate hyperactivity behaviors of these two animal models, and decrease the content of dopamine in striatum.