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新肌松药拮抗剂Org 25969的临床研究进展 被引量:1

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作者 邓佳 刘斌
出处 《实用医学杂志》 CAS 2007年第1期134-135,共2页 The Journal of Practical Medicine
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参考文献14

  • 1Bom A,Cameron K,Clark J K,et al.Chemical chelation as novel methodof NMB reversal-discovery of Org 25969[J].Eur J Anesthesiol,2001,18(Supp123):99.
  • 2Cameron K S,Fletcher,Fielding L,et al.Chemical chelation as a novel method of NMB reversal characterization of the Org 25969 NMB complex[J].Eur J AnesthesioL,2001,118 (Suppl 23):99.
  • 3Bom A,Mason R,Hope F,et al.The Cyclodextrin derivative Org 25969,which forms complexes with steroidal neuromuscular blocking agents,causes selective reversal of normal and profound neuromuscular block[J].Anesthesiology,2002,95:A1020.
  • 4van Egmond J,van de pol F,Booij L,et al.Neuromuscular blockade induced by steroidal NMBs can be rapidly reversed by Org 25969 in the anaesthetized monkey[J].Eur J Anesthesiol,2001,18(Suppl 23):A100.
  • 5de Boer H D,van Egmond J,van de pol F,et al.Chemical encapsulation of rocuronium by synthetic cyclodextrin.derivatives:reversal of neuromuscular block in anaesthetized Rhesus monkeys[J].BJA,2006,96(2):201-206.
  • 6Gijsenber G H F,Ramael S,Bruyn S D,et al.Preliminary assessment of Org5969as a reversal agent for rocuronium in healthy male volunteers[J].Anesthesiololgy,2002,96:A1008.
  • 7Gijsenbergh F,Ramael S,Honwing N,et al.First human exposure of Org 25969,a novel agent to reverse the action of rocuronium bromide.Anesthesiology,2005,103 (4):695-703.
  • 8Shields M,Giovannelli M,Mirakhur P K,et al.Org 25969 (sugammdex),aselective relaxant and binding agent for antagonism of prolongded recuroniuminduced neuromuscular block[J].Br J Anaesthesia 2006,96(1):36-43.
  • 9Iben F S,Kathrine N,Per Bo L,et al.Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex:a dose-finding and safety study[J].Anesthesiology,2006,104 (4):667 -674.
  • 10Mas O N R,Bom A.Org 25969 causes selective reversal of neuromuscular block induced by steroidal NMBs in the anaesthetized guinea pigs[J].Eur J Anestbesiol,2001,18 (Suppl 23):A100.

同被引文献19

  • 1Epemolu O, Bom A, Hope BF, et al. Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org25969. Anesthesiology, 2003,99 : 632-637, discussion 636 A.
  • 2Boer HD,Egmond J,Pol F, et al. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. Anesthesiology, 2006,104 : 718-723.
  • 3Boer HD, Egmond J, Pol F, et al. Time course of action of sugammadex ( Org 25969) on rocuronium - induced block in the Rhesus monkey, using a simple model of equilibration of complex formation. Br J Anaesth ,2006,97:681-686.
  • 4Born A, Mason R, Hope F, et al. The cyclodextrin derivative Org25969, which forms complexes with steroidal neuromuscular blocking agents, causes selective reversal of normal and profound neuromuscular block.Anesthesiology ,2002,95 : A1020.
  • 5Miller S, Born A. Org25969 causes selective reversal of neuromuscular block induced by steroidal NMBs in the mouse hemi - diaphragm preparation. Eur J Anesthesiol,2001,18 :A100.
  • 6Gijsenbergh F, Ramael S, Bruyn SD, et al. Preliminary assessment of Org25969 as a reversal agent for rocuronium in healthy male volunteers. Anesthesiolagy ,2002,96 : A1008.
  • 7Groudine SB,Soto R, Lien C, et al. A randomized dose - finding phase Ⅱ study of the first selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium - induced neuromuscular block. Anesth Analg,2007,104:555-562.
  • 8Sorgenfrei IF,Norrild K, Larsen PB, et al. Reversal of rocuronium - indueed neuromuseular bloek by the seleetive relaxant binding agent sugammadex: a dose- finding and safety study. Anesthesiology, 2006, 104:667-674.
  • 9Shields M, Giovannelli M, Mirnkhur PK, et al. Org25969 ( sugammadex),a selective relaxant binding agent for antagonism of prolongded recuronlum- induced neuromuscular block. BT J Anaesthesia,2006, 96:36-43.
  • 10lben FS, Kathrine N, Per Bo L, et al. Reversal of rocuronium - induced neuromuscular block by the selective relaxant binding agent sugammadex:a dose - finding and safety study. Anesthesiology, 2006, 104 : 667-674.

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