摘要
本文观察了八种抗生素在次最低抑菌浓度（Ｓｕｂ－ＭＩＣ）下对双歧杆菌和体外培养肠上皮细胞间粘附的影响。结果表明，次最低抑菌浓度的抗生素均能显著地抑制双歧杆菌的粘附，青霉素和万古霉素对双歧杆菌粘附的抑制有剂量及时间效应。提示抗生素抑制双歧杆菌的粘附可能是其引起肠道微生态失衡的一条重要途径。
Effect of subinhibitory concentrations of antibiotics on the adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells was investigated. Results showed that subinhibitory concentrations of antibiotice may decrease bifidobacterial adhesion to intestinal epithelial cells in vitro significantly. Penicillin and vancomycin reduced bifidobacterial adhesion to intestinal epithelial cells dose-dependently and time-dependently. The results suggest that antibiotics might influence intestinal bacterial microecology by mechanism of inhibition of bifidobacterial adhesion to intestinal epithelial cells.
出处
《中国微生态学杂志》
CAS
CSCD
1996年第5期4-6,共3页
Chinese Journal of Microecology
关键词
双歧杆菌
粘附
抗生素
Bifidobacteria Adherence Antibiotics
