摘要
本文报导了以4′-去甲表鬼臼素-4-β-D-葡萄糖甙分别与二甲醇缩乙醛和噻吩甲醛反应合成抗肿瘤药物依托泊甙(Vp-16)和替尼泊甙(Vm-26)中得到的两个主要副产物Vp-x和Vm-x的结构鉴定,并对其反应机理进行了探讨。
In the sythesis of Anti-tumor agents Etoposide (Vp-16)and Teniposide (Vm-26) from 4'-Demethyl-podophylloxin with relevant aldehyde,two by-products (Vp-x and vm-x) were obtained in the yields about 20 percents,their structures were elucidated and their machanisms were disscussed.
出处
《天然产物研究与开发》
CAS
CSCD
1996年第4期16-19,共4页
Natural Product Research and Development
关键词
生化药物
鬼臼素衍生物
合成
副产物
结构
机理
Podophylloxin derivates synthesis,Etoposide ,Teniposide, by-products, Vp-x, Vm-x. structures, Mechanism.
