脂蛋白a和血栓形成的相关性研究

Study on the relationship between lipoprotein(a) and thrombosis

目的:探讨血清脂蛋白a含量与血栓形成之间的相关关系及阿司匹林对他们的影响。方法:选择血清脂蛋白a大于300 mg/L的患者80例,应用血栓仪形成体外血栓,检测血栓的长度和湿重。患者口服阿司匹林治疗3个月后(100 mg/d),同样检测血清脂蛋白a水平及模拟血栓长度和湿重。结果:阿司匹林治疗前,血清脂蛋白a水平,血栓的长度、湿重分别为(450.83±104.907)mg/L,(36.04±11.009)mm,(113.15±49.112)mg;治疗后分别为(375.66±92.603)mg/L,(24.45±7.353)mm,(81.58±36.805)mg,前后比较均有统计学意义(P<0.01)。服药前后血清脂蛋白a水平与血栓长度和湿重均呈正相关,相关系数服药前分别为0.608,0.523,服药后分别为0.635,0.486。结论:血清脂蛋白a浓度与体外血栓大小呈正相关,阿司匹林能降低血清脂蛋白a,对血栓形成可能有一定的预防作用。

Objective： To study the correlation between concentration of Lp（a） and thrombogenesis and the influence of oral aspirin medication. Methods： We studied 80 Chinese patients （males and females） with high serum Lp（a） concentrations （ 〉300 mg/L） whose vitro thrombus were measured in weight and length. All patients were given 100 mg of aspirin daily for three month, the serum Lp（a） ,weight and length were measured again. Results： Before treatment, the level of serum Lp （a）, length and wet mass in vitro thrombus were （450.83 ±104.907） mg/L,（36.04 ±11.009 ） mm,（113.15 ±49. 112） mg, respectively ; after treatement they were （75.66 ± 92.603 ） mg/L, （24.45 ± 7. 353 ） mm, （ 81.58 ± 36. 805 ） mg, respectively. They were significantly decreased as compaired with before treatment（P 〈0.01, respectively）. The level of serum Lp （a） was positively correlative with wet mass and length in vitro thrombus both before and after treatment. The correlation coefficient were 0. 608,0. 523 before treatment and 0. 635,0. 486 after treatment, respectively. Conclusion： The level of serum Lp（a） was positively correlative with thrombogenesis. Low- dose aspirin could decrease the level of serum Lp（a） and prevent thrombogenesis.