益气活血汤治疗气虚血瘀证不稳定型心绞痛的临床研究

Clinical Study on the Treatment of the Unstable Angina Pectoris of the Qi-deficiency and Blood-stasis Syndrome with Yiqi Huoxue Decoction

目的:观察益气活血汤治疗气虚血瘀证不稳定型心绞痛的疗效。方法:选择气虚血瘀证不稳定型心绞痛患者44例,随机分为治疗组和对照组,两组均常规给予抗血小板、抗凝、调脂、抗心绞痛及对症治疗,治疗组在给予上述药物治疗的基础上,加用益气活血汤分早晚2次口服,1剂/d。两组均分别观察其疾病疗效及心绞痛、心电图、中医证候疗效,同时观察治疗前后血糖、血脂等指标变化。结果:治疗组中医证候疗效、心绞痛症状疗效均明显优于对照组(P<0.05)。治疗组在降低TG、Tch、LDL-c方面较对照组明显(P<0.05,P<0.01),在疾病疗效、心电图疗效、降糖、升高HDL-c方面与对照组比较无明显差异(P>0.05)。结论:益气活血汤可有效防治不稳定型心绞痛,并具有一定的改善脂质代谢作用。

Objective： To observe the effect of Yiqi Huoxue decoction in treating unstable angina pectoris （UAP） of the Qi-deficiency and blood-stasis syndrome. Methods：Forty four patients with unstable angina pectoris of the Qi-deficiency and blood-stasis syndrome were randomly chosen and divided into two groups： Treatment group and control group. Both two groups were treated with conventionally therapeutic methods, including antiplatelet, anticoagulation, lipidemic-modulating, antiangina and symptomatic treatment. Simultaneously the Yiqi Huoxue decoction was added into the treatment group twice a day with one dose. The therapeutic effect, antiangina effect, changes of electrocardiogram and effective rate of main symptoms of traditional Chinese medicine are detected. Blood glucose and blood lipid were measured and compared before and after treatment. Results： The effective rate of main symptoms of traditional Chinese medicine and the antiangina effect in treatment group were better than that of the control group （P 〈 0. 05）. The treatment group was superior to the control group in decreasing TG,Tch, LDL-c （ P 〈 0. 05 , P 〈 0. 01 ）, but was the same almosfly as the control group in the way of the therapeutic effect of disease and changes of electrocardiogram, the effect of degrading blood glucose and adjustment of HDL-c （P 〉 0. 05）. Conclusion： The therapeutic effect of Yiqi Huoxue decoction in treating UAP of the Qi-deficiency and blood-stasis syndrome was significant, and its working mechanism may be related to the adjusting metabolic disorder of lipid.