氟西汀合并利培酮治疗强迫症对照研究

Fluoxetine plus risperidone in the treatment of obsessive-compulsive disorder

目的评价氟西汀合并利培酮对强迫症的治疗效果。方法将符合CCMD-3诊断标准的60例强迫症患者随机分为治疗组和对照组,治疗组给予氟西汀合并利培酮治疗,对照组只给予氟西汀治疗,应用汉密尔顿焦虑量表(HAMA)及耶鲁布朗强迫量表(Y-BOCS)定期评定疗效。应用副反应量表(TESS)评定不良反应。疗程8周。结果在治疗第2、4、6、8周末,治疗组疗效优于对照组,尤其是对强迫思维疗效更好,具有显著性统计学意义(P<0.05)。结论氟西汀合并利培酮治疗强迫症效果优于单用氟西汀治疗。

Objective To explore the effect of fluoxetine plus risperidone in the treatment of obsessive-compulsive disorder. Methods A total of 60 outpatients who met the criteria of CCMD-3 for obsessive-compulsive disorder were assigned to therapeutic group（n=30） and control group （n=30） for the treatment of 8 weeks. Therapeutic group was given fluoxetine in addition to risperidone,and control group was fluoxetine alone. The clinical effect was assessed with HAMA and Y-BOCS at the end of 2^nd ,4^th ,6^th and 8^th week. The adverse reaction was evaluated by TESS. Results The therapeutic efficacy in fluoxetine plus risperidone group was significantly higher than that in control group, especially in the treatment of obsessive thoughts. Conclusion Fluoxetine plus risepridone has better effect in the treatment of obsessive-compulsive disorder than fluoxetine only.