帕罗西汀合并利培酮治疗强迫症对照研究

A study of risperidone combining with paroxetine in the treatment of obsessive-compulsive disorder

目的评价帕罗西汀合并利培酮治疗强迫症的临床效果。方法将53例强迫症患者随机分为治疗组与对照组,两组分别为27、26例,治疗组给予帕罗西汀合并利培酮治疗,对照组单用帕罗西汀治疗,应用临床疗效标准及耶鲁布朗强迫量表(Y-BOCS)定期评定,观察12周。结果12周末时,治疗组的显效率及有效率分别为62.9%、85.2%,均高于对照组;在治疗后2、4、8、12周末时,两组Y-BOCS评分均显著降低,尤以治疗组明显,在治疗各时段Y-BOCS的减分率,治疗组均高于对照组。结论帕罗西汀合并利培酮联合治疗强迫症疗效优于单用帕罗西汀治疗,对于强迫症的治疗,小剂量利培酮不失为一种有效的增效剂。

Objective To explore the efficacy of risperidone combining with paroxetine in the treatment of obsessive-compulsive disorder. Methods A total of 53 outpatients who met the criteria of CCMD-3 for obsessivecompulsive disorder were assigned to therapeutic group and control group for 12 weeks. Therapeutic group were given risperidone combining with paroxetine, and control group given paroxetine only. The clinical effect was assessed with Y-BOCS at the end of 2^nd ,4^th, 8^th and 12^th. Results After treatment, the marked improvement rate and effective rate in therapeutic group were higher than those in control group. There were significant differences in the reduction rates of Y-BOCS total scores between two groups at the end of 2^nd ,4^th ,8^th and 12^th. Conclusion Paroxetine combining with risperidone has better effect in the treatment of obsessive-compulsive disorder than panoetine only. Low dose risperidone is dn effective potentiation in the treatment of obsessive- compulsive disorder.