奥曲肽治疗重症非静脉曲张性消化道出血40例疗效观察

Management Of massive non-variceal upper gastrointestinal haemorrhage with octreotide(sandostatin),A report of 40 cases

目的：为了观察奥曲肽（善得定）治疗重症非静脉曲张性上消化道大出血的疗效，本文总结了４０例重症非静脉曲张性上消化道大出血的治疗结果，所观察者均为高龄及手术高危患者。方法：本组患者均给予奥曲肽治疗，剂量为１００μｇ，每６小时一次，静脉滴注，持续应用３天。结果：４０例中，３７例出血停止，总止血率为９２．５％，仅３例无效（其中２例施行手术治疗，１例死亡）。未发现明显的毒副反应。结论：奥曲肽不仅对静脉曲张性出血有效，且对非静脉曲张性消化道大出血如炎症、溃疡、血管畸形引起的出血亦有较好的疗效，可降低急诊手术率和死亡率．

Purpose:To evaluate the effects of octreotide in the treatment of massive non-variceal upper gastrointestinal haemorrhage,40 patients were treated with octreotide. Materials and methods:All patients were of high surgical risk on theirage and debility,in particular,those accompanied by other systemic diseases.Octre-otide was given at a dosage of l00μg intravenously once every six hours for 3 days.Results: Bleeding was controlled in 37 cases,2 were treated surgically afterwards and ldeceased. No side effects were found. Octreotide is effective not only in the treatmentof variceal bleeding,but also in severe non-variceal hemorrhage due to inflammation,ulceration, angiodysplasia,the operative and mortality rate can thus be decreased.