高压氧治疗毒鼠强中毒性脑病的临床观察

Clinical effect of hyperbaric oxygen in the treatment of toxic encephalopathy induced by tetamine

目的探讨高压氧治疗在毒鼠强中毒遗留中毒性脑病中的作用。方法对60例毒鼠强中毒的病例进行回顾性分析,随机分成两组,治疗组(常规治疗药物+高压氧治疗)30例及对照组(常规药物治疗)30例。结果分别于发病后15、30、60、90 d对患者进行评价,治疗组中毒性脑病的发生率分别为33.33%,16.67%,3.33%,0%,对照组分别为66.67%,53.33%,26.67%,20.00%,两组差异有统计学意义。结论毒鼠强中毒在常规治疗基础上,应及早应用高压氧治疗,可减少神经系统后遗症,减少中毒性脑病的发生。

Objective To explore the effect of hyperbaric oxygen in the teatment of toxic encephalopathy induced by tetramine. Methods 60 patients with tetramine poisoned were studied retrospectively. The patients were divided randomly into treatment group and control group. 30 patients in hyperbaric oxygenation therapy group were treated with hyperbaric oxygen besides the routine therapy. 30 patients in control group were treated with routine therapy. Results Assess to patients in 15,30,60 and 90 days after poisoned. The morbidity of toxic encephalophy in hyperbaric oxygen therapy group were： 33.33%, 16. 67%, 3.33% ,0%. The morbidity of encephalophy in control group were 66. 67% , 53.33%, 26.67%, 20%. There were significant differences between the treatment group and the control group. Condusion Hyperbaric oxygen treatment should be used early in patients with tetramine poisioned and it will shorten the combination of centrol nervous system and toxic encephalopathy.