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米力农对儿童体外循环围术期胃黏膜的作用研究 被引量:1

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摘要 目的:研究米力农在接受体外循环(CPB)的先天性心脏病儿童胃黏膜缺血缺氧损伤中的作用。方法:20例择期行心脏直视手术的先天性心脏病儿童(3~11岁)随机分为米力农组(M组,n=10)和对照组(C组,n=10)。M组静脉给予米力农0.25μg/(kg·min),C组给予等量生理盐水。两组均于CPB前(T1)、转流后30min(T2)、停机后30min(T3)、术后6h(T4)取胃液在血气分析仪上测得胃液二氧化碳分压,同时测动脉血重碳酸根离子浓度。根据Henderson-Hasselbalch方程式算出胃黏膜pH值(pHi)并将各时点胃液用免疫法进行隐血试验。结果:C组与M组相比pHi降低(P<0.01)。pHi各时点组内比较,C组T2、T3与T1相比均有降低(P<0.01),T4与T1差异无显著性(P>0.05),T3与T2相比有降低(P<0.05);M组T3与T1相比有降低(P<0.05),T2、T4与T1,T3与T2差异均无显著性(P>0.05)。隐血试验,C组和M组差异有显著性(P<0.05)。结论:小剂量米力农[0.25μg/(kg·min)]对接受CPB的先天性心脏病儿童胃黏膜损伤有保护作用,且此剂量对血流动力学没有明显影响。
作者 高阳 陈胜喜
出处 《实用医学杂志》 CAS 2007年第2期262-264,共3页 The Journal of Practical Medicine
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