Graves病眼球突出患者血清FT3、FT4、STSH、TGAb、TPOAb、TRAb检测的临床意义

Clinical significance of determination of sera FT3, FT4, STSH. TGAb, TPOAb, TRAb in exophthalmos patients with Graves disease

目的探讨FT3、FT4、STSH、TGAb、TPOAb、TRAb在Graves病（GD）患者伴眼球突出发生中的价值。方法采用放射免疫分析法检测72例GD伴眼球突出患者、88例GD患者及20例正常对照组血清FT3、FT4、S-TSH、TGAb、TPOAb、TRAb值，并对三组各指标的检测值及两组患者TRAb的阳性检出率进行比较。结果两组患者血清FT3、FT4、STSH、TGAb、TPOAb值明显高于正常对照组（P〈0．01）；两组患者间差异无显著意义（P〉0．05）。血清TRAb值在三组间两两比较差异均有显著性（P〈0．01）。GD伴眼球突出组明显高于另外两组（P〈0．01）。两组患者血清TRAb阳性检出率分别为86．11％和60．22％，GD伴眼球突出组明显高于GD组（P〈0．01）。结论两组患者甲状腺均呈高分泌状态；血清TRAb值在GD伴眼球突出的诊断中具有重要价值；血清TRAb值的显著增高可考虑为诊断或／和预测GD伴眼球突出发生的指标之一。

Objective To investigate the value of sera FT3、 FT4, STSH, TGAb、 TPOAb、 TRAb in exophthalmos patients with GD. Methords Sera FT3、 FT4、 STSH、 TGAb、 TPOAb, TRAb levels were measured and compared in 72 exophthalmos patients with GD, 88 GD patients as well as 20 controls by radio-receptor assay. Results Sera FT3, FT4, STSH、 TGAb、TPOAb levels in two patients groups were significantly higher compared with the items in control group （p〈0.01）. Sera TRAb levels in exophthalmos patients group were significantly higher than in other two groups （p〈0.01）. Positive rate of TRAb was 86.11% in exophthalmos patients group and 60.22% in GD patients group. The difference was significant （p〈0.01）. Conclusion Sera TRAb levels may play a critical role in the diagnosis of exophthalmos patients with GD.