5-氟尿嘧啶治疗人羊膜移植后翼状胬肉复发的临床研究

Clinical study of 5-floxuridine on the treatment of recurrent pterygia after the human amniotic membrane transplantion

目的观察5-氟尿嘧啶用于人羊膜移植后复发性翼状胬肉治疗的临床疗效。方法362例379眼翼状胬肉患者行翼状胬肉切除术联合羊膜移植术，其中初发性翼状胬肉例346眼，复发性翼状胬肉33眼。术后36例复发，复发率9％。对复发病例采用5-氟尿嘧啶结膜下注射，定期随访观察。结果36例复发病例5-氟尿嘧啶注射后，随访6～24月，痊愈加显效24例（有效率67％），9例有效（25％），3例无效。2例发生穹窿缩短，1例接受自体角膜干细胞移植加羊膜移植治愈。7例5-氟尿嘧啶注射后多发性角膜上皮点状脱落，停药后6例24～48小时愈合，1例点用表皮生长因子1周后痊愈。结论5-氟尿嘧啶结膜下注射是治疗羊膜移植后复发性翼状胬肉一种安全、简便、有效的方法。

Objective To investigate the effects of 5-floxuridine on the treatment of recurrent pterygia after anmiotic membranes transplantation. Methods The pterygial resection combined with amniotic membrane transplantation was performed on pterygial patients （379 eyes）, including 346 primary pterygial patients and 33 recurrent pterygial patients. After operation; 36 eyes recurred. The recurrent pterygial patients were treated with 5- floxuridine subconjunctivally. Results The treated patients with recurrent pterygia were followed up 6~24 months. The recurrent pterygia in 24 eyes （67%） stopped development. No serious side effects occurred. Conclusion The subconjunctival use of 5-floxuridine is an useful method for the treatment of recurrent pterygia.