曲美他嗪对冠状动脉介入术过程中血清白细胞介素6和C反应蛋白的影响

Effects of trimetazidine on serum levels of IL-6 and CRP of UAP patients undergoing precutaneous coronary intervention

目的：观察曲美他嗪对不稳定型心绞痛患者冠状动脉介入术（PCI）过程中血清白细胞介素6（IL-6）和C反应蛋白（CRP）浓度的影响。方法：75例拟行PCI治疗的不稳定型心绞痛患者，随机分为曲美他嗪组和对照组，分别于PCI前、术后即刻（0h）、2h和6h采取冠状静脉窦血样测定血清IL-6的浓度；另于术前、术后6、24和48h采取肘静脉血样，测定血清CRP的浓度。血清IL-6和CRP的浓度均以ELISA双抗体夹心法进行测定。结果：2组患者临床特征及靶病变情况差异无统计学意义。对照组IL-6浓度在术后即刻开始高于曲美他嗪组，术后2h和6h差异进一步增大（P〈0．05～0．01）。对照组的CRP浓度在术后6、24和48h都明显高于曲美他嗪组（P〈0．05～0．01）。结论：曲美他嗪能抑制不稳定型心绞痛患者PCI过程中血清IL-6和CRP浓度的升高。

Objective：To exploreithe effects of trimetazidine on serum interleukin-6（IL-6） and C-reactive protein（CRP） levels of unstable angina pectoris （UAP） patient undergoing precutaneous coronary intervenetion （PCI）. Method： A total of 75 UAP patients were randomly divided into trimetazidine group and control group. Coronary sinus blood was collected before angioplasty, 2 h and 6 h after angioplasty to measure the content of IL- 6. Veins blood was collected before angioplasty, 6 h, 24 h and 48 h after angioplasty to measure the serum content of CRP. The serum levels of IL-6 and CRP were measured by ELISA. Result：There was no significant difference of the target lesions or the clinic characteristics between the two groups. The serum level of IL-6 was significantly higher in control group than that in trimetazidine group immediate after angioplasty , also keep raising at 2 h and 6 h （P〈0. 01）. The serum level of CRP was significantly higher in control group than that in trimetazidine group at 6 h as well as 24 h and 48 h（P〈0. 01） . Conclusion：The results suggest that trimetazidine significantly reduce the production of IL-6 and CRP during PCI, which may account for the lower rate of cardiovascular events after trimetazidine treatment.