银杏达莫对急性脑梗死病人血浆氧化修饰低密度脂蛋白水平的影响

Effects of Ginkgo biloba leaf extract and diphyridamole injection on concentration of plasma oxidized low density liporotein in patients with acute brain infarction

目的:观察银杏达莫注射液对脑梗死病人血浆氧化修饰低密度脂蛋白(OX-LDL)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平的影响。方法:72例急性脑梗死病人分为试验组(36例,静脉滴注银杏达莫注射液20 mL·次-1,qd,连续14 d)和对照组(36例,每日静脉滴注丹香冠心注射液20 mL,连续14 d),于治疗前和治疗后14 d分别检测血浆OX-LDL,SOD,MDA的水平变化。结果:试验组病人治疗前血浆OX-LDL,SOD,MDA水平分别为(0．69±s 0．20)mg·L-1,(80±6)kU·L-1,(6．4±1．3)μmoL·L-1,治疗后分别为(0．54±0．23)mg·L-1, (107±9)kU·L-1,(4．1±1．0)μmoL·L-1,治疗前后有非常显著差异(P<0．01);对照组治疗前后血浆OX-LDL,SOD和MDA水平变化不明显(P>0．05)。治疗期间2组病人均未出现明显不良反应。结论:银杏达莫注射液具有清除自由基,降低血浆OX-LDL水平的作用。

AIM： To observe the effects of Ginkgo biloba leaf extract and diphyridamole injection on the levels of plasma oxidized low density liporotein （OX-LDL）, superoxide dismutase （SOD）, and malondialdehyde （MDA） in patients with acute cerebral infarction. METHODS： Seventy-two patients with acute brain infarction were divided into treatment group （treated with Ginkgo biloba leaf extract and diphyridamole injection, 20 mL, iv, gtt, qd, n = 36） and control group （treated with Danxiang Guanxin injection, 20 mL, iv, gtt, qd, n = 36）. All the patients were treated for 14 d. The levels of plasma OX-LDL, SOD, and MDA were tested before and after treatment. RESULTS： In treatment group the levels of plasma OX-LDL, SOD, MDA before treatment were （0.69 ± s 0.20） mg·L^-1, （80 ± 6） kU·L ^-1, （6.4 ± 1.3） μmoL·L^-1, and those after treatment were （0.54 ± 0.23） mg·L^-1, （107 ± 9） kU·L^-1, （4.1 ± 1.0） μmoL·L^-1, resulting with a great difference between them （P 〈 0.01）. No significant statistical differences were found in the above mentioned assessment indexes in control group before and aftert treatment （P 〉 0.05）. No remarkable adverse reactions occurred during this study in both groups. CONCLUSION ： Ginkgo biloba leaf extractand diphyridamole injection can effectively clear out the free radicals and decrease the level of the plasma OX-LDL.