生存素、组织蛋白酶-D在正常及异常子宫内膜的基因表达

Gene expression of SVV and Cath-D in normal and Abnormal endometrium

目的探讨生存素(SVV)和组蛋白酶-D(Cath-D)在正常及异常子宫内膜的表达差异与癌变的生成及侵袭和转移的关系。方法用SP免疫组化法对10例正常子宫内膜3、5例不典型增生子宫内膜及50例原发性子宫内膜腺癌组织进行了SVV和Cath-D检测。结果SVV和Cath-D在正常子宫内膜阳性率分别为10.00%和20.00%;不典型增生子宫内膜中阳性率分别为51.43%和91.43%;在子宫内膜腺癌中阳性率分别为68.00%和66.00%。SVV和Datthc-D在子宫内膜腺癌组织中的表达阳性率显著高于正常子宫内膜组织(P<0.05);在子宫内膜不典型增生组织中的表达阳性率均显著高于正常子宫内膜组织(P<0.05)。子宫内膜腺癌的分级、分期及有否淋巴转移与SVV和Cath-D表达有关(P<0.05)。结论SVV和Cath-D表达对判断子宫内膜癌变、恶性程度和预测肿瘤侵袭转移是一种良好指标。

Objective To explore the relations between Gene expression of SVV and Cath-D in normal and abnormal endometrium and canceration.aggression and metastasis.Methods The immunohistochemical method was used to detect SVV and Cath-D norreal endometrium（10）,atypital hyperplasia endometrium（35）,the primary endometrium adenocarcimoma. Results The positive rote of SVV and Ca th-D in normal endometrium was separately 10.00% ,20.00% ;as soon as 51.43 %, hyperplasia endometrium and the primary endometrium adenocarcimoma is higher difference than normal endometrium（P 〈 0.05）.The grade,substage,lymph metastasis was rehted with the expression of SW and Cath-D. Condusion SVV and Cath-D arc good index that arc used to judge canceration,malignancy degree and prredicting aggression metastasis of endometrium adenocarcinomo.