摘要
了解上皮性卵巢癌（EOC）预后因素能协助其个体化治疗，从而改善长期生存。近期大量研究提供了更多的预后指标：CA125水平这一经典肿瘤标记物被赋予新的预后意义；DNA倍性、人类表皮生长因子受体-2（HER-2）和p53等多种分子生物学指标在提示肿瘤生物学行为的同时也能预示预后，而基因芯片技术的发展更提供了高效、准确的预后指示。
To improve survival of patients with ovarian carcinoma,effective prognostic factors are required. Many researches reveal more prognostic factors：kinetic parameters of serum CA125 concentration, serum CA125 concentration combined with other serum makers, DNA-ploidy, human epithelial growth factor receptor- 2, p53 gene expression and its polymorphism,the serum concentration of metalloproteinase and its tissue inhibitor, expression of methylation of tumor suppressor gene p16, gene expression tests and so on. Among these new indexes for prognosis and biological behaviors of tumors, gene expression tests may be of the most effect and accuracy.
出处
《国际肿瘤学杂志》
CAS
2007年第2期134-137,共4页
Journal of International Oncology
关键词
卵巢肿瘤
幸存
预后
Ovarian neoplasms
Survival
Prognosis
