caspase-7、survivin在乳腺癌中的表达及相关性研究

Expression of caspase-7,survivin in breast neoplasm and their relationship with other biomarkers.

目的探讨乳腺癌中caspase-7s、urvivin的表达及ER、PR、Cerb-B2、P53、Ki-67的关系。方法免疫组织化学法检测乳腺癌石蜡标本中caspase-7s、urvivin的表达,并分析与上述标志物的关系。结果34例乳腺癌中caspase-7、sur-vivin阳性率分别为73.53%、76.47%。仅caspase-7、P53间显著相关(r=0.403,P=0.018),在P53阳性组与阴性组中cas-pase-7表达高低差异显著(P=0.001),其余指标间无相关性。结论caspase-7和survivin在乳腺癌中作用不同,均可作为靶向治疗的选择,两者与上述标志物的关系及其作用机制需进一步研究。

Objective This paper is to explore expression of easpase-7, survivin in breast neoplasm and their relationships with these biomarkers. Methods Expression of caspase-7, survivin in 34 patients with breast cencer was examined by immunohistochemical staining.Their relationship with biomarkers,sueh as ER,PR,Cerb-B2,P53,Ki-67,was analyzed.Results Expression of caspase-7,sur- vivin was 73.53% ,76.47%, respectively.The correlation between expression of easpase-7 and P53 was statistically significant（ r = 0.403, P = 0.018） .Significant difference of the rate of easpase-7 expression between positive and negative P53 was seen （ P = 0.001 ）. Conclusion Caspase-7, survivin play different roles in breast neoplasm. It is necessary to study their relationship with biomarkers.