前列腺素E1治疗继发性肺动脉高压超声学评价

Echocardiographic evaluation of prostaglandin E1 therapy on secondary pulmonary hypertension

目的观察前列腺素E1(PGE1)治疗继发性肺动脉高压的疗效。方法选择不同病因的继发性肺动脉高压患者14例分成两组(各7例),分别予PGE1加常规治疗及只用常规治疗,比较治疗前后的超声学指标。结果PGE1治疗组治疗后三尖瓣返流速度降低(t=6.25,P<0.001),三尖瓣跨瓣压差降低(t=4.08,P<0.01)。两组治疗前后两次三尖瓣返流速度的差值(△TR))和跨瓣压差的差值(△TGP)进行组间比较,差异有显著性意义(P<0.05)。结论在常规治疗的基础上联合使用PGE1可以明显降低继发性肺动脉高压。

Objectives To evaluate the therapeutic effects of prostaglandin E1 （ PGE1 ） on secondary pulmonary hypertension. Methods Fourteen patients with secondary pulmonary hypertension enrolled in this trial were randomized to treatment with PGE1 in addition to conventional therapy （n = 7 ） or conventional therapy alone （n = 7 ）. Echocardiographic data were obiained in both groups before and after therapy for further statistical analysis. Results Patients in PGE1 group had a lower value of tricnspid regmrgitant jet velocity （t =6.25, P 〈 0.001） and tricuspid gradient pressure （t = 4.08,P 〈 0.01） after therapy compared with the original data obtained before therapy. The differences of tricuspid regurgitant jet velocity （ATR） and gradient pressure （ATGP） in PGE1 group before and after therapy were larger than those of conventional therapy group （P 〈 0. 05）. Conclusion Combined use of PGE1 with conventional therapy has much stronger efficacy in the treatment of secondary pulmonary hypertension.