ezrin,c-Met及ICAM-1在胃癌组织中的表达及其意义

Expressions of ezrin,c-Met and ICAM-1 proteins in gastric carcinoma and their significances

目的:探讨ezrin,c-Met及ICAM-1在胃癌组织中的表达及意义.方法:应用免疫组化检测ezrin,c-Met及ICAM-1在正常胃黏膜(n=15),不典型增生胃黏膜(n=50)及胃癌组织(n=75)中的表达.结果:正常胃黏膜、不典型增生胃黏膜及胃癌组织中,ezrin和c-Met阳性率有递减趋势,组间差异有统计学意义(χ2=33.319,P<0.001;χ2=19.913,P<0.001);ICAM-1蛋白阳性表达率有递增趋势,组间差异有统计学意义(χ2=16.409,P<0.001).Fisher精确概率检验显示在不同的肿瘤大小、浸润深度和淋巴结转移组内ezrin,c-Met及ICAM-1阳性表达率组内差异有统计学意义(P<0.05),而在年龄、性别和脉管侵犯组内差异无统计学意义(P>0.05).Spearman等级相关分析显示ezrin与c-Met表达呈正相关(r=0.880,P<0.05),ezrin与ICAM-1表达呈负相关(r=-0.735,P<0.05),c-Met与ICAM-1表达无相关性.结论:ezrin与c-Met的缺失以及ICAM-1的过表达与胃癌的发生发展及浸润转移有关.

AIM： To study the expressions and clinical significances of ezrin, c-Met and ICAM-1 proteins in gastric carcinoma. METHODS： The expressions of ezrin, c-Met and ICAM-1 proreins were detected by immunohistechemistry in normal gastric mucesa （ n = 15 ）, atypical gastric hyperplasia （ n = 50） and gastric carcinoma （ n = 75 ）. RESULTS： The positive expression rates of ezrin and c-Met proteins in normal gastric mucosa, gastric hyperplasia and gastric carcinoma were gradually decreased, and statistical difference among the 3 groups was significant （ χ^2 = 33. 319, P 〈 0. 001 ; χ^2= 19. 913, P 〈 0. 001 ） ; the positive expression rate of ICAM-1 protein was gradually increased with significant statistical difference （χ^2 = 16. 409, P 〈0. 001 ）. The expressions of ezrin, c-Met and ICAM-1 proteins were related to the malignant progression of gastric carcinoma, tumor diameter and lymph node metastasis （ P 〈 0.05 ）, but not correlated with patient＇s age, gender and vessel invasion （P 〉0. 05）. In addition, the expression of ezrin protein was positively correlated with that of c-Met protein （ r =0. 880, P 〈0.05 ）, but negatively correlated with that of ICAM-1 protein （ r = - 0. 735, P 〈 0.05 ）. CONCLUSION： The loss of ezrin and c-Met expressions and the over-expression of ICAM-1 protein play an important role in the development of gastric carcinoma.