CXC趋化因子与肿瘤血管新生

CXC Chemokines and Angiogenesis of Cancer

趋化因子在免疫调节、血管新生以及介导肿瘤的器官特异性转移中发挥重要作用。其中CXC趋化因子超家族由于N-端谷氨酸-亮氨酸-精氨酸基序(Glu-Leu-Arg,ELRmotif)的有无使其在血管新生过程中具有了促进或者抑制血管新生的不同作用:含有ELR(ELR+)的CXC趋化因子经血管内皮组织上CXCR2介导血管新生促进作用;而不含有ELR(ELR-)的CXC趋化因子通过血管内皮组织上CXCR3介导血管新生抑制作用。

Chemokines play important roles in the regulation of immunity, angiogenesis and mediation of organ-specific metastases of cancer. The CXC chemokine family can promote or inhibit the angiogenesis, in the presence or absence of the glutamic acid-leucine-arginine motif （ Glu-Leu-Arg, ELR motif） at the NH2-terminus. The CXC chemokines with ELR （ELR ＋ ） are promoters of angiogenesis, and mediate their angiogenic activity via CXCR2 on endothelium. Nevertheless, the CXC chemokines without ELR （ELR-） are inhibitors of angiogenesis, and, through CXCR3 on endothelium, can mediate their angiostatic activity.