不同牵张速率对山羊下颌骨牵张成骨中新骨形成的影响

Effects on the new bone formation by different distraction rate during mandibular distraction osteogenesis in goats

目的:探讨山羊下颌骨牵张成骨中不同牵张速率对术后新骨形成的影响。方法:12只山羊随机分为3组,每组各4只,在对动物右下颌骨行骨皮质切开术后进行牵张,第1组动物以0.8mm/d的牵张速率进行牵张,第2组动物以1.6mm/d的牵张速率进行牵张,第3组动物以2.0mm/d的牵张速率进行牵张,随机选取实验组4只动物未手术侧正常下颌骨作为对照组。将各组新骨组织和对照组下颌骨组织分别进行骨密度检测和三点弯曲测试,对采用不同速率进行骨牵张后动物下颌骨新骨的生物力学强度和骨密度进行了对比观察。结果:0.8mm/d牵张组新骨骨密度值显著高于其余各牵张组,0.8mm/d牵张组新生骨三点弯曲实验指标均大于另2牵张组。结论:采用0.8mm/d的牵张速率进行牵张能最快促进新骨形成,提高成骨质量。

Objective：To investigate the effects on the new bone formation by different distraction rate during mandibular distraction osteogenesis in goats. Methods： The right side mandibles of twelve goats were distracted after corticortomy, and all the animals were divided into 3 groups randomly, the first group were distracted with 0.8 mm/day, the second group were distracted with 1.6 mm/day, the third group were distracted with 2.0 mm/day, and the left side mandible of 4 goats from above groups were selected randomly as the control group. Then the new generation bone after distraction with different rate were studied by bone density examination and three point bending test. Results： The bone density value of the 0.8 mm/day group were higher than the other two experimental groups ; the results of three point bending test showed that the biomechanical strength of the new generation bone in 0.8 mm/day group was higher than the other two experimental groups. Conclusion ：0.8 mm/day may be the best distraction rate in mandibular distraction osteogenesis.