皮肤巨淋巴结病性窦组织细胞增生症

A case of cutaneous Rosai-Dorfman disease

报告1例皮肤巨淋巴结病性窦组织细胞增生症。患者女,47岁。面颈部无痛性棕黄色斑块3年,无淋巴结增大及其他系统受累。皮损组织病理检查显示真皮全层及皮下组织中有大量组织细胞浸润,其间有淋巴细胞及浆细胞,并可见组织细胞内吞噬淋巴细胞及浆细胞。免疫组化染色结果示组织细胞S-100蛋白、CD68均阳性。皮损组织分枝杆菌PCR扩增、分枝杆菌培养及真菌培养均为阴性。诊断:皮肤巨淋巴结病性窦组织细胞增生症。

Acase of cutaneous Rosai-Dorfman diseuse（CRDD）is reported.The 47-year old female patient presented with painless,brown-red mass on the face and neck for 3 yesrs ,without lymphadenopathy and other systemic abnormdlities.Mierosopically,many histiocytes.lymphoeytes and plasma cells were noted intradermally and aubcutaneously.The major feature was the phagocytosis of intact lymphocytes and plasma cells by unique histocytes.Immunohistochemical staining shoued that these histiocytes were positive for S-100 and CD68.Polymerase chain reaction （PCR） for mycobacteria and cultures for both myeobacteria and fungi were all negative.CRDD is a rare.benign proliferating disease of histiocytes.The understanding of the clinical manifestations,histopathological features and immunobistologyical findings of this disease will be helpful for accurate diagnosis.