脑星形细胞瘤患者术后生存质量影响因素分析

An analysis of the influencing factors of the postoperative quality of life of in patients with astrocytoma

目的分析星形细胞瘤术后影响生存质量的因素，为全面评价手术效果提供依据。方法对近4年住院行星形细胞瘤切除术后资料齐全的患者400例，按生存质量量表所列项目进行随访，随访时间为6—48个月，所得生存质量评分经计算机进行统计学分析。结果最终有198例参与生存质量分析，按WHO对星形细胞瘤的分级，Ⅰ级96例，Ⅱ级54例，Ⅲ～Ⅳ级48例。病灶部位：额叶90例，颞叶42例，顶叶24例，小脑18例，脑干12例，脑室12例。复发行2次或2次以上手术者84例，死亡42例。结论影响星形细胞瘤术后生存质量的主要因素为手术方式与手术切除程度、组织病理学特征、术前患者的神经功能状态、肿瘤的大小和位置、肿瘤复发情况及术后放疗和化疗次数等。

Objective To analyze the factors influencing the postoperative quality of life （PQOL） of patients with astrocytoma. Methods Four hundred patients after the operation for astrocytoma were followed up from 6 months to 48 months, and PQOL was analyzed with SPSSll. 5 by computer. Results One hundred and ninety-eight cases were recruited in the analysis of PQOL, of them 96 cases were classified as grade Ⅰ, 54 cases grade Ⅱ and 48 cases grade Ⅲ- Ⅳ. The location of the tumor of 90 cases was in the frontal lobes, 12 cases in the temporal lobes. Eighty cases were recrudesce and operated twice or more, and 42 cases were dead. Conclusion The major factors, influencing PQOL of astrocytoma are operative mode and the range of the resection in the operation, the histological characteristics and recurrence of the tumor, preoperative neurological functional status, postoperative pathological form, size and the location of the tumor, postoperative radiotherapy and chemotherapy.