摘要
用D-氨基半乳糖致大鼠肝损伤,以研究rhKD/APP对大鼠肝损伤的保护作用。建立D-氨基半乳糖大鼠肝损伤模型,设空白对照组、模型组、rhKD/APP小剂量组、中剂量组、大剂量组、对照药物抑肽酶组。观察大鼠血清丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、总蛋白(TP)、碱性磷酸酶(ALP)、白蛋白(ALB)及肝组织丙二醛(MDA)的含量变化。rhKD/APP可显著降低大鼠血清ALT、AST、ALP的活性及肝组织MDA含量,抑制ALB、TP的降低。rhKD/APP对D-氨基半乳糖所致大鼠肝损伤具有保护作用。
To investigate the protective effect of rhKD/APP on liver injured by D - galactosamine in rats. The rat liver injury model was induced by D - galaetosamine, rhKD/APP was given by different dose, compared with controls and aprotinin. The levels of ALT, AST, TP, ALB, ALP in serum and MDA in hepatic tissue were mesured, rhKD/APP can significantly decresease the activities of ALT, AST, ALP, and the content of MDA, and inhibit the decrease of ALB and TP. rhKD/ APP has a protective effect on liver injured by D - galaetosamine in rats.
出处
《临床肝胆病杂志》
CAS
2007年第1期24-25,共2页
Journal of Clinical Hepatology