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CENP-F过度表达与脑膜瘤生成及增殖活性的相关性 被引量：1

Correlation of overexpression of CENP-F to genesis and proliferation activity of meningiomas
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摘要 目的探讨着丝粒/动粒复合体蛋白F(CENP-F)表达与脑膜瘤的生成及增殖活性之间的关系。方法采用免疫组化方法检测65例脑膜瘤和10例正常脑组织石蜡标本的CENP-F表达,并采用逆转录聚合链反应(RT-PCR)方法检测11例新鲜脑膜瘤和10例新鲜正常脑组织标本中的CENP-F。结果CENP-F在脑膜瘤中表达明显高于正常脑组织,随着肿瘤病理分级的增加,CENP-F表达的阳性率和表达水平也增高(P<0.05)。结论人类CENP-F的过度表达与脑膜瘤的生成及增殖活性之间存在着一定的关系。 Objective To explore correlation of the expression of CENP-F with genesis and proliferation activity of meningiomas. Methods The expression of CENP-F was detected by immunohistochemistry in 65 paraffin-embedded tumor tissues from patients with meningiomas and 10 normal brain tissues from patients with brain injuries, and 11 fresh meningioma tissues and 10 fresh normal brain tissues were detected for CENP-F by RT-PCR. Results The expression of CENP-F in meningiomas was significantly higher than that in the normal brain tissues, and positivity rate and level of the expression were raised with increase of pathological grade of tumor（P〈0.05） Conclusion Theoverexpression of human CENP-F is possibly associated with genesis and proliferation activity of meningiomas.
作者 胡再虎 万经海 王晓健 李长元 肖瑾
机构地区 安徽医科大学第一附属医院神经外科 中国医学科学院协和医科大学肿瘤医院神经外科
出处 《中国微侵袭神经外科杂志》 CAS 2007年第2期79-81,共3页 Chinese Journal of Minimally Invasive Neurosurgery
关键词 脑膜瘤 着丝粒/动粒复合体蛋白F 免疫组织化学 逆转录聚合酶链反应 meningioma centromere/kinetochore complex protein-F immunohistochemistry , reverse transeriptase pdymerase chain reaction
分类号 R739.4 [医药卫生—肿瘤]
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参考文献11

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共引文献3

同被引文献14

  • 1索新,郭永川,孟令秋,郭宏川.血管内皮生长因子在人脑胶质瘤的定位及表达[J].中华实验外科杂志,2004,21(9):1100-1102. 被引量：8
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  • 4高文宏,陈谦学,刘刚.内皮抑素和血管内皮生长因子在脑胶质瘤中的表达及意义[J].中国临床神经外科杂志,2006,11(2):86-87. 被引量：6
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中国微侵袭神经外科杂志
2007年 第2期

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