组织间插植与CP方案诱导化疗治疗Ⅲ_A期大菜花型宫颈癌的疗效比较

COMPARING INTRAHISTOIMPLANTATED RADIOTHERAPY WITH CP NEOADJUVANT CHEMOTHERAPY ON Ⅲ_A BULKY EXOPHYTIC CERVICAL CANCER

目的:比较组织间插植与环磷酰胺+顺铂(cyclophosphamide cisplatin,CP)方案诱导化疗治疗肿瘤直径≥4cm的ⅢA期菜花型宫颈癌的疗效。方法:63例经病理诊断的大菜花型ⅢA期宫颈癌患者分为放疗前组织间插植组及放疗前CP诱导化疗组,比较两组完全缓解(CR)、局部缓解(PR)及1年生存率。结果:组织间插植组32例中达到CR者18例(占56.2%),达到PR者12例(占37.5%),生存时间≥1年者29例(占90.6%),死亡3例;放疗前诱导化疗组31例中达到CR者9例(占29.0%),达到PR者4例(占12.9%),其余消退不足50%,生存时间≥1年者19例(占61.3%),死亡12例。放疗前组织插植组CR、PR及1年生存率均显著高于放疗前CP诱导化疗组(P<0.05)。结论:大菜花型局部晚期宫颈癌患者组织间插植的局部控制效果优于CP诱导化疗方案。

Objective：To compare the intrahistoimplantated radiotherapeutic effect with the effect of CP neoadjuvant chemotherapy on ⅢA bulky exophytic cervical cancer.Mothods ：Sixty -three patients of ⅢA bulky exophytic cervical cancer with diameter 4 -7cm （mean 5.5cm） were divided into two groups,treated with intrahistoimplantated therapy before radiotherapy and CP neoadjuvant chemotherapy before radiotherapy, respectively.Results：The complete resolution rates （CR） of intradiotherapy and CP neoadjuvant chemotherapy groups were 56.2% and 29.0%, respectively. While the partial resolution ratesn （PR） of them 37.5% and 12.9%, respectively. The rates of survival over one year were 90.6% and 61.3%, respectively. All of the data are statistically significant （P〈0.05）.Gonclusion ：The effect of intrahistoimplantated radiotherapy is better than that of CP neoadjuvant chemotherapy on ⅢA bulky exophytie cervical cancer.