急性期毛细支气管炎患儿IL-13水平的观察

Serum Interleukin-13 Levels in Infants with Acute Bronchiolitis

目的探讨急性期毛细支气管炎患儿白细胞介素-13(Interleukin-13,IL-13)的变化及与病情轻重的关系,以及IL-13在本病发生中的作用。方法(1)分组:42例毛细支气管炎患儿为观察组,其中有22例轻症组(临床评分<6分),20例重症组(临床评分≥6分);16例年龄匹配的健康婴儿为对照组(无过敏史和哮喘病家族史)。(2)用ELISA法检测血清IL-13的含量。结果(1)观察组血清IL-3的含量为(6.88±2.12)ng/L,正常对照组为(5.48±1.28)ng/L,两组比较IL-13增高差异有统计学意义(P<0.05)。但轻症组和重症组分别为(7.11±1.95)ng/L、(6.64±2.24)ng/L,两组比较差异无统计学意义(P<0.05)。结论毛细支气管炎急性期患儿血清IL-13含量明显增高,提示IL-13参与了毛细支气管炎的发病过程,但IL-13不能反映病情严重程度。

Objective To observe the change of serum IL-13 in infants with acute bronchiolitis and to investigated the possible effect of IL-13 in acute bronchiolitis. Methods 42 infants with acute bron- chiohiolitis from 2 months to 12 months were divided into two groups according to the clinical severity score： the mild bronchiolitis group and the severe bronchiolitis group. 16 healthy infants were selected as control group. The serum leves of IL-13 were detected by enzyme linked immunosorbent assay. Results The serum levels of IL-13 in acute bronchiolitis patients （6. 88±2. 12） ng/L were significantly higher than those in the healthy infants （5. 48±1.28）ng/L （P〈0. 05）. The mean IL-13 concentration, however, was similar between mild group and severe group （7. 11±1. 95 ng/L vs 6. 64± 2. 24 ng/L）. Conclusion Serum levels of IL-13 were increased in acute bronchiolitis and IL-13 may be involved in the pathophysiologic processes of the disease. But, there was no relationship between the serum concentrations of IL-13 and the clinical severity of the disease.